Herpes zoster can potentially cause swollen lymph nodes in the clavicle. Herpes zoster is an infectious skin disease caused by varicella zoster virus infection. If herpes zoster occurs in the skin around the clavicle, it can cause localized neuroinflammatory reactions, resulting in symptoms such as neuralgia, herpes, and ulcers, and due to the inflammatory stimulus, it is possible that the clavicular lymph nodes may become enlarged. However, not all herpes zoster will cause clavicular lymph node enlargement, for example, herpes zoster in other parts of the body, may cause the corresponding parts of the neighboring lymph nodes enlarged, if the symptoms of herpes zoster around the clavicle is atypical, the lesions are light, it may be just a skin abnormality, will not lead to clavicular lymph node enlargement. Herpes zoster, it is recommended to seek timely medical treatment, follow the doctor’s instructions to choose antiviral drugs, shorten the course of the disease, and prevent complications.