There is no specific medicine for chronic renal failure, but only comprehensive treatment to improve the condition, slow down the development of the disease, prevent and control complications, and take different measures for different problems. The basic countermeasures are: (1) treatment of etiology: for example, for hypertension, glomerulonephritis, etc., insist on long-term rational treatment. (2) Avoid or eliminate the risk factors for the rapid deterioration of CRF. (3) Delay the progression of the disease. Wuhan Tongji Hospital, Department of Nephrology, Ma Zufu diet to maintain a high-quality low protein intake, protein intake is generally 0.6-0.8g/kg.d, animal protein can account for 50% to 60%, in order to increase the proportion of essential amino acid intake. Control the production of toxins from the source. It can be added with a-keto acid, which generates essential amino acids with NH2 and helps to reuse urea nitrogen and improve protein nutrition; as a-keto acid contains calcium salts in the production column, it is also effective in correcting disorders of calcium and phosphorus metabolism and reducing secondary hyperparathyroidism. Appropriate water intake to maintain urine volume of 1500-2000 ml under the premise of high urine volume, no edema, and no weight gain to promote the excretion of toxins. Oral oxidized starch or activated charcoal preparations and oral rhubarb preparations can be applied to increase the excretion of uremic toxins by the gastrointestinal route. These therapies are mainly applied to patients with chronic renal failure before dialysis and play a supplementary role in reducing azotemia in patients, but they should not be relied on as the main means of treatment. Correction of acidosis and water and electrolyte disorders. Correction of various complications such as anemia, improvement of microcirculation, etc.