The first symptom of chronic renal failure in children is digestive discomfort, patients usually show anorexia, nausea, vomiting and diarrhea, in addition, some patients will show the smell of urine and gastrointestinal bleeding and other discomforts. The common symptoms of chronic renal failure in children are also manifested in the child chronic renal failure patients with psychoneurological discomfort, for example, the patient is likely to show mental depression, dizziness, headache and memory loss and insomnia, numbness of the limbs and itchy “restless legs” and so on a series of symptoms, and often may have In addition, difficulty in urination is also a common manifestation of chronic renal failure in children, and even coma is likely to occur in severe cases. Cardiovascular discomfort is also a common symptom after suffering from chronic renal failure in children, patients are often accompanied by hypertension, heart failure, palpitations and signs of shortness of breath, usually the patient can not lie down, the rhythm of the heart is also abnormal, serious patients often appear pericardial effusion, and may even occur pericardial tamponade symptoms. Children with chronic renal failure also often outbreak of hematopoietic system discomfort, often showing severe anemia, advanced patients may even have a tendency to bleed from various organs. Children with chronic renal failure also often have problems with the respiratory system, usually children with chronic renal failure whistle gas have a great smell of urine, may have metabolic acidosis of the whistle. How can chronic renal failure be treated in children? The use of angiotensin-converting enzyme inhibitors such as captopril and enalapril can effectively lower blood pressure, greatly reduce the degree of glomerulosclerosis, and also reduce proteinuria. The long-term use of sodium bisulfate can effectively correct acidosis, minimize the formation of ammonia, and effectively improve protein and uric acid metabolism.