Chronic kidney disease may not have any special symptoms at the initial stage, and often some corresponding symptoms will appear gradually due to the continuous decline of kidney function. Common chronic kidney diseases include like microscopic lesion nephropathy, membranous nephropathy, IgA nephropathy and so on, all of which will gradually appear edema, elevated blood lipids, hematuria, proteinuria and so on. Due to the late onset of symptoms and slow progression of the above diseases, there may be transient hematuria followed by gradual improvement of symptoms. A few people may have persistent hematuria and proteinuria, or even hypertension and anemia due to the gradual aggravation of renal impairment. In the chronic kidney disease treatment difficulties or aggravation of the phenomenon, about ten years after the onset of the disease will progress to chronic renal failure. Even in the early stage of chronic renal failure, there are often no clinical symptoms except lithiasis. When the condition develops to the point that the kidneys cannot regulate the minimum requirements of the organism, the symptoms of uremia will be gradually manifested, including the digestive system such as nausea and vomiting, disturbance of the water-electrolyte balance, hypertension, heart failure, pericarditis, anemia, white blood cell abnormality, skin symptoms, symptoms of renal osteodystrophy, endocrine dysfunction, concurrent infections, and abnormalities of lipid metabolism, etc. In conclusion, in addition to the development of chronic kidney disease, chronic kidney disease is also characterized by the presence of lithiasis. In a word, chronic kidney disease not only has urinary symptoms, but also has the above mentioned systemic symptoms.