Diet for advanced chronic kidney disease is a very complex and specialized subject, which is usually assessed comprehensively with the type of kidney disease, daily urine output, nutritional status and co-morbidities. Because of the complexity, patients are often deterred. Here are some simple principles that are easy to understand. Diet in the advanced chronic renal failure stage needs to be formulated according to whether dialysis is available or not. If the general condition is poor and combined with malnutrition, dialysis should be started and nutrition should be strengthened, otherwise malnutrition will seriously affect the quality of life. If the general condition is good and there is no malnutrition, a high-quality low-protein diet should be carried out, which simply means that the protein intake per kilogram per day is at 0.6g (as shown in the picture, the sliced meat is about 200g, containing 28g of protein). The simplest principle is: if you do not eat eggs or milk, no more than 150g of meat per day; if you eat an egg or drink a carton of 250ml of milk, reduce 50g of meat accordingly. Meat is best in fish, followed by chicken and duck. If the amount of urine is reduced, you should avoid foods with a lot of water and high potassium content. At the stage of chronic renal failure, all treatments are aimed at slowing down the progression of kidney disease, and the current level of medical care is not able to reverse kidney function. On top of the chronic lesions, malnutrition, infection, anemia, hypertension and urinary tract obstruction will aggravate renal insufficiency. Treating these factors may be able to reduce creatinine, but it is difficult to return to normal levels. Blood creatinine often rises at an accelerated rate in advanced renal failure, and most patients with blood creatinine over 450 μmol/L need to start dialysis within 1 year. High-quality low-protein can delay the dialysis time, but it cannot “cure” the original kidney disease. Even if the diet is arranged strictly according to the principle of high quality and low protein, with the development of the original kidney disease, dialysis will be needed eventually.