High immunoglobulin A may be closely related to rheumatoid arthritis, systemic lupus erythematosus, cirrhosis of the liver, etc. IgA has antibacterial, antitoxic and antiviral effects, and may also have effects on mycoplasma and certain fungi. 1. Rheumatoid arthritis: High immunoglobulin A can be seen in rheumatoid arthritis, which may be related to genetic, autoimmune, infection, smoking and other factors. Patients often show morning stiffness, joint swelling, pain and other symptoms. 2. Systemic lupus erythematosus: high immunoglobulin A can also be considered to be caused by systemic lupus erythematosus, which can be due to the formation of pathogenic autoantibodies and immune complexes and mediate the damage of organs and tissues, and clinically there are often multi-systems involved in the performance of the patients usually appear fever, rash, lymph node enlargement, muscle and joint pain and other symptoms. 3. Cirrhosis: High immunoglobulin A may also be caused by cirrhosis. Patients usually have symptoms such as fatigue, loss of appetite, diarrhea, spider nevus and so on. There are many other reasons for high immunoglobulin A. It is recommended that patients consult a doctor in time to find out the reasons and follow the doctor’s instructions for standardized treatment.