CREST syndrome is a subtype of systemic scleroderma and derives its name from the disease’s typical manifestations of calcium salt deposits, Raynaud’s phenomenon, esophageal motor dysfunction, finger end sclerosis, and capillary dilation, most commonly seen in women and in young adults aged 20-30 years. Patients present with cutaneous calcium deposits, connective tissue disorders such as dermatomyositis and scleroderma, specifically CREST syndrome with cutaneous calcium salt deposits, arteriospasm of the extremities, scleroderma of the finger ends and capillary dilation. Arterial spasticity and ischemic symptoms appear in both hands, due to sympathetic nerve dysfunction innervating the peripheral blood vessels causing spastic disease of the small arteries of the extremities, and esophageal dysfunction manifested by esophageal motility disorders, reduced contractility and peristalsis.