Early pregnancy reaction is an annoying problem for many first-time mothers, and it usually occurs around 6 weeks of pregnancy. Most of them have mild symptoms, such as nausea, acidity and vomiting in the morning, which do not require special treatment and disappear naturally around the 12th week of pregnancy. A small number of pregnant women have severe early pregnancy reactions and persistent vomiting, resulting in dehydration and electrolyte disorders such as low blood potassium; because they cannot eat, their bodies use fatty tissues to supply energy, resulting in the accumulation of ketone bodies, an intermediate product of fat metabolism, causing metabolic acidosis and the appearance of ketone bodies in the urine, which affects the health of pregnant women and is medically known as acute pregnancy-related vomiting. The cause of pregnancy reaction is still not clear, but it may be related to the dysfunction of the hypothalamic autonomic nervous system of pregnant women and the sharp increase of hormones such as blood HCG (human chorionic gonadotropin), but the severity of symptoms varies greatly among individuals. Pregnant women with mental stress, emotional instability and poor economic conditions are prone to it, suggesting that mental and social factors have an influential role in its development. Therefore, both psychological comfort and medical treatment are very important for patients with severe pregnancy vomiting. Once a pregnant woman has vomiting that is difficult to relieve, her family should, on the one hand, stabilize the situation, try to overcome their own anxiety and bad mood, and give more mental support and care to the pregnant woman to overcome the difficulties together; on the other hand, cooperate with the doctor’s treatment while preparing the diet regulation when the condition improves. Generally, after one to two days of treatment, symptoms and signs such as vomiting will be significantly improved, and family members need to give easy-to-digest food and small and frequent meals according to the preferences of pregnant women. In addition, hyperemesis gravidarum may recur during early pregnancy. If the symptoms are obvious and you do not eat enough, you should still go to the hospital for rehydration support treatment. The key to treating severe pregnancy vomiting is early and correct diagnosis. The physician will do the appropriate tests according to the condition to exclude nausea and vomiting caused by diabetic ketoacidosis, chronic gastritis, esophagitis, enteritis, acute viral hepatitis, gastrointestinal obstruction, intracranial lesions and other medical and surgical diseases. After the diagnosis is clear, timely individualized treatment is given to help pregnant women safely pass the uncomfortable early pregnancy period, which will not affect the normal growth and development of the baby and can continue the pregnancy. Unless a patient with severe pregnancy vomiting does not improve after timely treatment, with an increased body temperature of 38°C or higher, a heart rate of more than 120 beats per minute, persistent jaundice or proteinuria, termination of pregnancy should only be considered for the mother’s own safety.