Pregnant and lactating women should be more cautious with medication According to the literature, in the past, some pregnant women in Europe took the drug thalidomide (reaction stop) to avoid early pregnancy reaction, resulting in nearly 10,000 cases of tragic seal abnormal fetuses, thus causing medical concern about the use of medication for pregnant and lactating women. It has been proved that the adverse effects of certain drugs on pregnant women, fetuses and nursing children should never be taken lightly, so pregnant and lactating women should avoid using drugs as far as possible, and if they must use drugs, they should strictly follow medical advice and choose drugs with low side effects and high safety. 1, the impact of drugs on pregnant women Clinical evidence shows that some antibiotics and antipyretic analgesics can cause serious harm to pregnant women themselves should be prohibited. For example, the use of tetracycline in pregnant women can cause liver metabolic disorders and high mortality; the incidence of hepatotoxic reactions caused by the use of odorless erythromycin is 10-15%; the use of aspirin in late pregnancy can cause overdue pregnancy, prolonged labor, and postpartum hemorrhage. In addition, pregnant women are sensitive to laxatives, diuretics and caffeine-based drugs, which can cause preterm labor or miscarriage and should be used with caution. In order to ensure the development of the fetus and maintain the nutritional needs of the mother, appropriate supplements of iron, calcium, folic acid, vitamins B1 and B6 can be given to pregnant women in case of nutritional deficiencies. when pregnant women must use antipyretic and analgesic drugs, the safer acetaminophen (paracetamol) should be used. 2, the impact of drugs on the fetus Maternal nutrients are transported to the fetus through the placenta, and the drugs used by the mother are inevitably transferred to the fetus through the placenta, especially in the first trimester of pregnancy, which is particularly sensitive to drugs. The adverse effects of maternal drug use on the fetus are mainly teratogenic, hemorrhage, hemolysis and damage to the nervous system, hearing, vision, liver and kidney functions. In addition to the aforementioned thalidomide (reaction stop), there are some sex hormones, anti-cancer drugs, anti-epileptic drugs, anticoagulants; drugs that cause hemorrhage and hemolysis include sulfonamides, furans, aspirin, bicoumarins, vitamin K, etc.; drugs that cause neurological damage include some analgesics, tranquilizers, anti-allergic drugs; drugs that cause deafness and kidney damage include gentamicin antibiotics; drugs that affect Drugs that cause deafness and kidney damage include gentamicin antibiotics; those that affect tooth and bone development include tetracyclines; those that cause visual damage include chloroquine and chlorpromazine. In addition, overdose of vitamin D in pregnant women can cause excessive blood calcium, mental retardation, arterial stenosis and hypertension in newborns; oral hypoglycemic drugs can cause hypoglycemia in newborns; the use of thyroid drugs can cause goiter in newborns; the application of chloramphenicol before delivery can cause circulatory disorders and gray baby syndrome in newborns. Some Chinese medicines can also bring different degrees of harm to pregnant women and fetuses, for example, hemp, motherwort, peach kernel, musk, safflower, talc, rhubarb, and descending incense, etc., which should also be avoided. When pregnant women must use drugs, they should analyze and weigh the pros and cons under the guidance of a doctor, and choose relatively safe drugs; the duration of medication should be short rather than long, the dose should be small rather than large, and the medication for chronic diseases should be postponed until late pregnancy as far as possible; do not inject any vaccine if there is no clear infection. If teratogenic drugs are inadvertently used during early pregnancy, pregnancy interruption should be considered. 3, the impact of drugs on the nursing child after the drug into the breast milk of lactating women, most drugs in breast milk content is less than 2%, so it is not so harmful to the nursing child; but a few drugs in breast milk excretion is large, lactating women should be alert to the harm to the nursing child when taking. For example, indomethacin (anti-inflammatory pain) has caused cramps in infants and bromides have caused lethargy and rashes in infants. Other drugs that should be avoided by breastfeeding women are: antibacterial drugs such as erythromycin, kanamycin, tetracycline, chloramphenicol, sulfonamide, sedatives such as dexamethasone, phenobarbital, chlorpromazine, laxatives such as senna and castor oil, anti-allergic drugs such as iproniazid and diphenhydramine, and some hormonal and oral contraceptive drugs. When breastfeeding women must use medication, in addition to paying attention to the careful selection of drugs that enter the breast milk less, the time of medication should be chosen just after the end of breastfeeding, and the next breastfeeding interval of more than 4 hours, or consider the temporary use of artificial feeding method.