Generally, mild cholecystitis does not cause an increase in ghrelin, but when cholecystitis is more pronounced, it can cause an increase in ghrelin. Mild cholecystitis does not affect liver function, which does not lead to abnormalities in liver enzymes such as ghrelin. When the common bile duct or bile ducts are blocked, the bile that cannot be excreted backs up into the liver and impairs liver function, which leads to the release of ghrelin into the bloodstream from the liver cells, resulting in an elevation of ghrelin. However, if a patient with cholecystitis develops elevated ghrelin, other possibilities should also be considered, such as the combination of pancreatitis, or the liver function itself is impaired, such as previous chronic liver diseases such as hepatitis B, hepatitis C, and so on. For patients with elevated ASTE, it is recommended to consult a doctor and take tests to rule out other conditions, such as liver ultrasound and Hepatitis B pentameter for differential diagnosis, and to actively cooperate with the doctor in the treatment.