Syphilis is an infectious disease caused by syphilis spirochete infection, clinical treatment drugs include penicillin drugs, ceftriaxone sodium, tetracycline and macrolides. The medication needs to be administered as early as possible, in sufficient quantity and in a standardized manner. Penicillin class is the first choice of drugs for the treatment of syphilis, commonly used drugs include benzylpenicillin, aqueous penicillin G, procaine aqueous penicillin G and so on. For patients with penicillin allergy, ceftriaxone sodium can be replaced as an alternative drug for treatment, and tetracyclines and macrolides can also be used for treatment, but the efficacy is relatively poor. Pregnant women, children, and patients with liver and kidney insufficiency are prohibited from using tetracyclines for treatment. Syphilis patients need to be under the guidance of the doctor, follow the doctor’s instructions for standardized treatment.