After evaluation, esophageal cancer needs to be treated with immuno-combination radiotherapy and chemotherapy, and the treatment is beneficial, which can inhibit tumor proliferation and improve the patient’s prognosis. Radiotherapy, chemotherapy, immunotherapy and other measures are important parts of the comprehensive treatment of esophageal cancer, which involves multiple aspects of preoperative, postoperative, radical and palliative treatments. Through these non-surgical treatments, tumor proliferation can be limited, and the tumor may even be shrunken to buy time for surgery; for advanced esophageal cancer, survival time may also be increased, which is beneficial. However, not all esophageal cancers need immunotherapy combined with radiotherapy. Whether it is needed or not needs to be carried out needs to be analyzed by clinicians according to the stage of the disease, pathological examination, physical tolerance and so on. If immunotherapy combined with radiotherapy is needed, it is recommended to cooperate with doctors for active treatment.