There are physiological and pathological reasons for not urinating during the day but urinating a lot at night. Physiological causes mainly include not relieving urine before going to bed and drinking too much water before going to bed, which will result in frequent and large urine at night. Clinical symptoms can be eliminated by correcting the lifestyle, such as emptying the urine before going to bed and not drinking water one hour before going to bed. Pathological causes are common in acute urinary tract infections, where patients with urinary tract infections experience irritation of the urethra, even at night when the irritation can be very strong, with frequent, urgent, and excessive urination. Increased nocturia is also an early manifestation of chronic kidney disease, mainly due to the early stage of kidney damage, and decreased glomerular and tubular function will appear clinical manifestations. It is recommended to go to the hospital to do urine routine and kidney function tests, which can help to determine the condition initially.