Sleeping at night with calf pain may be due to the following reasons: 1. the calf itself, like fasciitis of the calf. Aseptic inflammation of the fascia can cause pain in the calf. 2. It may be a vascular problem, such as phlebitis, arteritis, venous embolism, and inflammation of these vessels can also cause local pain. 3. It may be a tumor, like a tumor of the bone, giant cell tumor of the bone, myeloma, synovial sarcoma, or a tumor of the muscle, like smooth muscle sarcoma, can cause pain in the calf. 4. It may also be rheumatoid, rheumatic, which can also cause pain in the calf. 5. Also can cause calf pain. 5, in addition, there are herniated discs, lumbar spinal stenosis, slipped vertebrae, stimulation of the nerve will radiate to the calf, causing calf pain. 6, there may also be immune diseases, which may cause pain in the calf. There are more specific causes, which need to be further determined after comprehensive examination and comprehensive analysis.