Klinefelter syndrome is primarily due to chromosomal lesions. Congenital varicocele syndrome is caused by the non-separation of sex chromosomes during meiosis of the parents’ germ cells to form sperm and egg. During maturation and division of the oocyte, the sex chromosomes do not separate, forming an egg containing two X’s, which, if combined with a Y sperm, forms a 47,XXY fertilized egg. If the spermatogonial cells do not segregate during maturation of the 1st maturation division XY, XY sperm are formed, and this sperm combined with an X egg can also form a fertilized egg of 47,XXY. The disease is characterized by small testes, infertility, gynecomastia, anencephaly-like body shape and hypermasculinity. In severe cases, the testes are small before puberty or at puberty there are signs of hypermasculinity and gynecomastia. There may be developmental delays and learning disabilities.47 Primary gonadal failure occurs in patients with XXY when plasma follicle-stimulating hormone and luteinizing hormone are increased and plasma testosterone is decreased. It is recommended that patients go to regular hospitals for treatment in a timely manner according to their symptoms, so as not to delay the condition and cause serious consequences.