Chew betel nut mouth can not open, consider oral mucosal fibrosis may be, oral submucosal fibrosis is a chronic disease, this disease fibrous tissue degeneration and epithelial atrophy, thus causing mucosal sclerosis. You can take general treatment, Vitamin A and other medications, and surgery if necessary. 1. General treatment: In addition to the inability to open the mouth, some of them also show pain, dry mouth, loss of taste, which will eventually lead to speech and swallowing difficulties. It is recommended to stop chewing betel nut immediately, eat a light diet and more vegetables and other vitamin-rich foods. 2. Medication: Vitamin E and B vitamins are helpful. Oral Vitamin A can reduce the symptoms. 3. Surgical treatment: patients with limited mouth opening can consider cutting off the fibrous strips and skin grafting on the wound. There are other possibilities, such as temporomandibular arthritis, if you can’t open your mouth when chewing betel nut. It is recommended to consult a doctor in time to clarify the diagnosis and use medication under the guidance of the doctor.