Male ligation may produce some side effects, such as wound infection, painful nodules, epididymal stasis, etc. Therefore, ligation surgery should be performed with caution. 1. Wound infection: Male ligation usually involves ligating the tubes for sperm transmission and then cutting off the pathway for sperm to be discharged. If proper care is not taken after the ligation surgery, the incision may become infected and painful sensations may occur. 2. Painful nodules: When male ligation is performed, the place where the vas deferens is cut off generates scar-like hyperplasia. If a hard nodule is felt, it is usually accompanied by a painful sensation, which needs to be notified to the doctor in time for treatment. 3. Epididymal stasis: after cutting off the vas deferens, the sperms produced by the testicles and the fluid produced by the epididymis cannot be discharged to the outside of the body through the vas deferens, and they are stagnated in the epididymis, and malabsorption in some patients may lead to the stagnation of the sperms and the fluid, which will result in the development of epididymal stasis. Men should communicate with their doctors in detail and follow the doctor’s instructions before ligation, and take good care of themselves after the ligation surgery without too much psychological burden. If the patient is not feeling well, he should consult the doctor for examination and early treatment.