Breathing will then appear to have painful symptoms. Clinically, it is still most common to have a series of diseases of the respiratory system, which cause pleurisy, pleural effusion or pneumatization, causing breathing pain. In addition, inflammation or trauma to the chest wall can also cause respiratory pain. The main common ones are inflammatory reactions of the respiratory tract, such as bronchitis, pneumonia, lung abscess, bronchopleural fistula, and bronchiectasis combined with severe infections. The most common of these pathogens are bacteria, viruses, protozoa, and even Mycobacterium tuberculosis, in addition to trauma that leads to rupture of the pleural cavity, resulting in pneumothorax. It is also seen in congenital pulmonary cysts, as the mucosal wall of the cyst is very fragile and easily ruptured by trauma, which can also cause different degrees of pneumothorax, resulting in hemothorax or even pneumothorax, or even secondary infection to form pneumothorax, so it can cause painful breathing.