There is no definite time limit for plasma cell myeloma to progress from early to advanced stages. Generally speaking, early detection and treatment will prolong the progression from early to advanced stages, and in general, it ranges from 3 to 10 years. The time from early stage to late stage of plasma cell myeloma is closely related to one’s own condition and the treatment measures taken. Plasma cell myeloma is a primary systemic bone marrow tumor that predominantly destroys bone. The most common symptom of isolated plasma cell tumors is localized pain, and patients with multiple myeloma often have pain in the peripheral bones, anemia, kidney impairment, and infection. For spinal solitary plasmacytomas presenting with pain and mild vertebral collapse, radiotherapy alone may be the mainstay of treatment in the early stages. Treatment of multiple myeloma is commonly based on physical condition, complications, and localized bone destruction, with chemotherapy and radiation therapy, with drugs including bortezomib and lenalidomide. Surgery may be required if the lesion causes severe spinal nerve compression or spinal instability. Plasma cell myeloma should go to a regular hospital in time, and the doctor will give the right treatment according to the specific condition to delay the progression from early to late stage.