Symptoms such as fatigue and sleepiness are experienced before menstruation. A woman’s menstruation is controlled by sex hormones. Before menstruation, estrogen and progesterone levels decrease simultaneously, and the endometrium loses hormonal support and undergoes necrosis. In addition to the changes in the endometrium, the nervous system is also affected by the negative feedback from the hypothalamus and pituitary gland, and cyclical changes occur. Typical symptoms are easy fatigue and sleepiness, and various symptoms such as breast tenderness, edema, irritability, and memory loss may also occur. These symptoms often appear in the week before menstruation and rapidly decrease or disappear after menstruation and are cyclical in nature, and are more common in women aged 25-45. In response to this physiological reaction, we can choose to rest more before menstruation to ensure sleep, and those with obvious symptoms can take oral vitamin B6 to regulate the relationship between hypothalamus, pituitary and nervous system can effectively improve the symptoms.