Vitiligo of the corners of the mouth is a chronic disease, the treatment cycle is long, the main use of drug therapy, transplantation therapy, phototherapy. 1. drug therapy: before treatment should be based on the patient’s condition to choose the appropriate treatment, including topical drugs and internal drug therapy, topical drugs mainly include glucocorticoid preparations, calcium-modulated phosphatase inhibitors such as pimecrolimus ointment, vitamin D3 derivatives, the progress of the stage can be oral glucocorticoids such as prednisone treatment. 2. Transplantation therapy: In the stable stage, autologous epidermis or melanocytes can be transplanted into the depigmented area to restore the color. 3. phototherapy: 308nm excimer laser is suitable for all types or kinds of vitiligo treatment, irradiation need to pay attention to the eyes, face and external genitalia and other parts of the protection. Vitiligo at the corner of the mouth should be timely consultation, under the guidance of the doctor for treatment, the use of medication need to comply with the doctor’s orders.