Trazodone may cause liver damage if not used properly. Trazodone has antidepressant properties and can be used to relieve symptoms such as depression, insomnia, and anxiety. Taking the drug may have an effect on liver function because the liver is the body’s detoxification organ, and the drug itself or the metabolites of the drug may cause damage to the liver. For patients with normal liver function, the use of the correct dosage as prescribed by the doctor usually does not cause drug-related liver injury. For patients with underlying liver disease, high dosage use may cause liver function damage. For drugs that may cause hepatic impairment, they need to be applied in accordance with medical advice. Trazodone is recommended to be used under medical supervision, not blindly self-medication to avoid adverse effects.