In kidney disease, most of the hypercoagulable state refers to patients with nephrotic syndrome, because of their large amount of proteinuria, hyperlipidemia, edema, and hypoproteinemia, which put the organism in a hypercoagulable state. The location of the thrombus is not certain. If the thrombus occurs in the brain, it is easy to induce cerebral infarction; if it occurs in the heart, it may cause myocardial infarction; if it occurs in the lower extremity, there is lower extremity venous thrombosis, etc. The hypercoagulable state of nephrotic syndrome can induce a variety of diseases, so anticoagulation therapy should be added to the treatment to prevent complications. In the treatment of nephrotic syndrome, anticoagulant drugs such as dipyridamole and low molecular heparin are often added, mainly to prevent the formation of thrombus in the hypercoagulable state of nephrotic syndrome.