Oral Mucosal Fibrosis Restricted Mouth Opening Treatment Depending on the severity take the removal of local irritants followed by the use of medication or surgery. 1. Remove irritating factors. You need to quit chewing betel nut, quit smoking and drinking, and avoid spicy and greasy food stimulation. 2. Medication. Oral mucosal fibrosis is mainly manifested as connective tissue collagen fiber degeneration, for mild symptoms can be taken to glucocorticoid injection, improve local ischemia, promote collagen synthesis. Or local injection of hyaluronidase and interferon. 3. Surgical treatment. Surgery is needed to remove the fibrous strips to improve the severe restriction of mouth opening. Oral mucosal fibrosis lesions need to be examined and treated in a specialized hospital as soon as possible to avoid aggravation of symptoms, and medication should be prescribed by the doctor.