The five lipids include total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides and very-low-density lipoprotein (VLDL) cholesterol. The clinical significance of different lipids is different, and there is no so-called “which is the most dangerous one”. 1. Total cholesterol: Total cholesterol can be used to assess the condition of blood lipids, and if elevated, can lead to cardiovascular and cerebrovascular diseases. 2. HDL cholesterol: It mainly transports cholesterol from peripheral tissues to the liver for recirculation, and has the effect of anti-atherosclerosis. Elevated HDL cholesterol is good for the prevention of coronary heart disease and cerebral thrombosis. If the index decreases, coronary heart disease, diabetes and other diseases may occur. 3. LDL cholesterol: LDL cholesterol is easy to enter into the arterial wall, gather in the blood vessels, and gradually lead to the formation of atherosclerotic plaque. 4. Triglycerides and very low-density lipoprotein (LDL) cholesterol: elevated triglyceridemia and very low-density lipoprotein (LDL) cholesterol may increase the incidence of atherosclerosis, leading to coronary heart disease and cerebral thrombosis. Elevated levels of any of these indicators, except HDL cholesterol, require active measures to control them in order to prevent the onset of disease.