Usually patients with chronic urticaria can be vaccinated when the disease is well controlled and non-acute episodes are present. If the lesions, itching and other manifestations are severe, or if angioedema is present, vaccination is not appropriate. In addition, the actual vaccination depends on the type of vaccine, and some vaccines have special contraindications, such as BCG vaccine is contraindicated for those with eczema, purulent otitis media and inflammatory skin diseases, which should be evaluated by a doctor. Patients with chronic diseases undergoing treatment or in poor health condition should withhold vaccination to avoid the immunogenicity of the vaccine to increase the body burden and discomfort. Chronic urticaria attacks are often characterized by windy, locally elevated, smooth, pink or red skin with a visible red halo around the skin. At this time the patient is in the period of allergy, the vaccine may aggravate the allergic reaction and induce serious adverse reactions. It is recommended that the patient’s condition be well controlled before vaccination, and antihistamines such as loratadine can be used for treatment under the guidance of a doctor. Chronic urticaria has a complex etiology and pathogenesis, and the allergens are widespread. Patients should try to avoid known triggering factors, such as food, drugs, and mental factors, in order to reduce recurrent urticaria. Patients should take their medications regularly during treatment and follow medical advice for vaccination after their symptoms have improved.