The difference between chronic enteritis and chronic colitis mainly lies in the lesion site, clinical manifestations, treatment methods and other aspects. 1. Site of lesions: chronic enteritis can involve all segments of the intestinal tract, including the small intestine (duodenum, jejunum, ileum) and the large intestine (cecum, colon, rectum); chronic colitis is limited to the colon, and part of the lesions can involve the rectum. 2. Clinical manifestations: the clinical manifestations of chronic enteritis mainly include abdominal pain, diarrhea or constipation, and those with rectal involvement may have symptoms of urgency and severity, and may be complicated by intestinal perforation and intestinal stenosis, etc. Chronic colitis is characterized by diarrhea and mucopurulent and bloody stools during the active period, which may be accompanied by abdominal pain, abdominal distension and other symptoms, and the complications are commonly seen such as toxic megacolon and colorectal cancer. 3. Treatment: individualized treatment measures should be taken. (1) chronic enteritis: including the treatment of bacterial infections, such as bacterial infections caused by the choice of antibiotics (such as amoxicillin) treatment; symptomatic treatment, such as diarrhea, severe correction of water-electrolyte imbalance and take antidiarrheal drugs (such as montelukast), abdominal pain, severe use of antispasmodic and analgesic drugs (such as atropine), and so on. (2) Chronic colitis: including acute treatment, such as correcting water-electrolyte disorders, parenteral nutrition, etc.; drug therapy, such as commonly used aminosalicylic acid preparations (e.g., salazosulfapyridine), glucocorticosteroids (e.g., prednisolone), etc.; surgical treatment is only applicable to the emergence of carcinoma or haemorrhage, intestinal perforation and other acute complications. In conclusion, the specific diagnosis and treatment of chronic enteritis and chronic colitis must be completed by professional doctors, and drugs should be used under the guidance of doctors to avoid adverse consequences.