High progesterone can be seen in patients with hyperemesis gravidarum, mild hypertensive syndrome of pregnancy, pregnant women with diabetes, adrenal cancer, Cushing’s syndrome, multiple ovulations, multiple pregnancies, essential hypertension, and congenital adrenocortical hyperplasia. Progesterone is an important progestin that not only plays an important role in the regulation of the menstrual cycle, but is also a hormone necessary for the maintenance of pregnancy. The measurement of progesterone is mainly used to determine ovulation, progesterone therapy monitoring and evaluation of early pregnancy status. It is important in determining the functional status of the corpus luteum and in the study of ovarian physiology and pathology. High progesterone should be examined by a doctor in a timely manner to clarify the condition and standardize the treatment under the guidance of a professional doctor.