The suitable painkillers for senior citizens vary from person to person. The application of painkillers needs to be selected according to the type of disease and pain level of the patient, such as ibuprofen, tramadol, morphine and so on. 1. Type of disease: common muscle pain, neuropathic pain can choose ibuprofen, diclofenac and other non-steroidal anti-inflammatory drugs for pain; some acute pain and post-surgical pain can be used to relieve pain such as tramadol and other central pain relievers; gastrointestinal and smooth muscle spasticity can be used to relieve pain such as atropine and other antispasmodic pain relievers. 2. Pain level: pain medication needs to be used according to the ladder of medication, the less severe pain is generally preferred to ibuprofen and other non-opioid drugs, when the drugs used or the dose can not achieve the effect of pain, can be added to Tramadol and other weak opioids, severe pain can be used in morphine, pethidine and other opioid painkillers. It is recommended that patients strictly follow the doctor’s instructions for medication, and it is strictly forbidden to change the dose of medication on their own to prevent serious adverse reactions.