Although there is no clear evidence of side effects caused by the interaction between loratadine and alcohol, since loratadine has been taken, it means that the human body has the indications for taking this drug, and most of the patients who take this drug need to take it orally due to allergic diseases or skin allergies, drinking alcohol may aggravate the patient’s Allergic reactive inflammatory changes, aggravating the condition. In the case of skin diseases, it can also aggravate the itching of the skin and the development of skin inflammation, for example, if the patient has urticaria, after drinking alcohol will cause the capillaries of the skin to dilate, which will cause further increase and aggravation of the wind mass, and will also stimulate the skin to produce significant itching symptoms.