Thickened toenails with white powder usually indicate a fungal infection, and patients need to seek antifungal treatment from a dermatologist promptly. Fungal infections are characterized by thickened toenails and powdered nails, and in some cases, fungal infections in the skin around the nails, resulting in flaking, itching, and blistering. Fungal infections are usually related to the environment and are contact diseases. High temperatures can also lead to increased fungal reproduction and worsen the patient’s symptoms. Antifungal treatment is usually divided into two categories, one is local medication, the application of local antifungal drugs can play a certain effect; the other category of more serious fungal infections may need to take systemic medication to kill the fungus, and should follow medical advice, pay attention to liver, kidney and other functional tests, reasonable adjustment of medication.