It is impossible to tell which is better, irinotecan or oxaliplatin, because the indications of the two drugs are different, and it is necessary to decide which drug to apply according to the specific condition and a combination of factors, such as pathology, staging, and the patient’s general state. Indications: Irinotecan is a semi-synthetic water-soluble camptothecin derivative, which is mainly used to be effective for 5-fluorouracil-resistant metastatic colorectal cancer and some other advanced tumors, such as lung, stomach, pancreatic and cervical cancer. Oxaliplatin is used for advanced colorectal cancer, but also for ovarian cancer, gastric cancer, pancreatic cancer, non-small cell lung cancer and so on. Adverse Reactions: Irinotecan, the most common adverse reactions are low white blood cells and platelets, which are hematologic toxicity, and can also cause gastrointestinal reactions such as loss of appetite, abdominal pain and diarrhea, nausea and vomiting, constipation, and stomatitis, as well as reactions such as malaise, alopecia, and joint and muscle aches, elevated aminotransferases, and allergies. Oxaliplatin can cause gastrointestinal reactions such as nausea and vomiting and diarrhea, as well as myelosuppression, effects on red blood cells, white blood cells and platelets, constipation, neurotoxicity such as dullness of sensation and sensory abnormalities. Contraindications: Irinotecan, is contraindicated for those who are allergic to irinotecan; oxaliplatin is contraindicated for nursing mothers, and oxaliplatin is contraindicated for those who are allergic to oxaliplatin. The application of irinotecan and oxaliplatin, it is recommended that you need to use the medication under the guidance of a doctor, and consult a doctor in time to clarify the diagnosis and treatment, so as not to delay the condition.