Blisters on the soles of the feet (medically known as blisters) are painful to walk on and may be caused by localized friction, trauma, or tinea pedis. This situation should minimize walking, according to the size of the blisters discretion to give disinfection, bandage and other symptomatic treatment, and need to be for the cause of the formation of blisters for treatment. 1. Pay attention to rest, reduce walking: when walking, the soles of the feet are subjected to friction and pressure, which can aggravate the pain, in this case pay attention to rest, minimize walking, in order to prevent aggravating the pain. 2. Symptomatic treatment: use povidone-iodine to sterilize the blisters locally, don’t pick the smaller blisters, use sterile gauze bandage, apply antibiotics locally such as erythromycin ointment, mupirocin ointment and so on to prevent infection. If the blister is large and inevitably ruptured, a sterile syringe can be used to draw out the liquid inside, and then sterilized, the wound coated with rehabilitation new liquid and antibiotic ointment and then bandaged, which helps to reduce pain. 3. Treatment of the cause: If the blisters are caused by local friction and trauma, symptomatic treatment can be done as mentioned above. In addition, blisters on the soles of the feet may also be caused by ringworm, which can be treated with topical antifungal therapy, such as ketoconazole ointment, terbinafine ointment and so on. When blisters on the soles of the feet, if the symptoms are serious, we should consult a doctor in time to avoid secondary infections, and the use of medication should follow the doctor’s instructions.