The causes of generalized muscle twitching are mainly seen in the following aspects: first, epilepsy, patients with previous epilepsy will have generalized muscle twitching during an acute seizure, accompanied by clenched teeth, foaming at the mouth, eyes rolled up, and in some cases, there are also consciousness disorders and dysfunction of urinary and fecal functions, and an EEG can be done to check the results. Second, the generalized muscle twitching, need to ask the patient whether there is an overdose of oral medication, oral overdose of sleeping pills, some patients will be manifested as generalized muscle twitching. Third, we need to ask the patient whether there are metabolic diseases, such as diabetes-induced alkalosis, some patients are prone to respiratory alkalosis in nervousness, hyperventilation, also easily manifested as generalized muscle twitching. In addition, some patients may also cause generalized muscle excitability to increase if they take certain chemicals by mistake, thus resulting in convulsions.