Waking up in the middle of the night with a burning sensation in the stomach may be related to gastroesophageal reflux (GERD), chronic gastritis, gastric ulcers and other factors, and it is important to choose the right way to deal with it according to the specific situation. 1. Gastroesophageal reflux: If the reflux mechanism between the stomach and the esophagus is broken, the gastric acid secretion is increased, the esophageal mucosa is damaged, and the stomach will have a burning sensation and pain, so you should keep a light diet before going to bed, and use the medicines such as Ranitidine, Omeprazole enteric-coated capsule, bismuth potassium citrate and other medicines to treat the problem under the suggestion of the doctor. 2. Chronic gastritis: Chronic and repeated damage to gastric mucosa will cause symptoms such as abdominal distension and abdominal pain with burning sensation, which can be treated with drugs such as amoxicillin capsule, lansoprazole enteric-coated tablets, aluminum magnesium plus suspension under doctor’s advice and guidance. 3. Gastric ulcer: Helicobacter pylori will cause serious damage to the gastric mucosa, resulting in increased secretion of gastric acid to appear gastric ulcer, stomach pain, loss of appetite, etc., accompanied by a burning sensation, if infected with Helicobacter pylori, the need for quadruple drug antimicrobial treatment, such as omeprazole + bismuth potassium citrate + metronidazole + clarithromycin. Daily life usually drink more water, diet should be regular, pay attention not to eat stimulation, greasy, spicy food. In addition, waking up in the middle of the night with a burning sensation in the stomach, you can eat and drink warm water, milk and other temporary relief, if the burning sensation can not be effectively relieved, you should go to the hospital in a timely manner for examination, to clarify the cause of the disease, symptomatic treatment, to avoid causing serious effects on the body.