The five-year survival rate of low-differentiated rectal adenocarcinoma is between 15% and 90% after treatment, and the specific survival time can be slightly different and cannot be generalized. Rectal adenocarcinoma is a common intestinal malignant tumor, and the occurrence of the disease is related to heredity, bad living habits, gene mutation and other factors. Hypofractionation means that the cancer cells are poorly differentiated from normal cells, with a higher degree of malignancy and a poorer prognosis. The treatment after diagnosis of the disease is comprehensive treatment mainly based on surgical resection. After active treatment, the specific five-year survival rate of rectal poorly differentiated cancer is highly related to the stage, such as about 90% in stage I; about 70% in stage II; about 40% in stage III; and only about 15% in stage IV. Therefore, early detection, early diagnosis and early treatment should be pursued to obtain a better prognosis.