Thick knee cuticle may be caused by excessive friction, skin dehydration, melanin precipitation, etc. It can be removed by general and medication methods, and the specific treatment needs to be chosen according to the cause. 1. Excessive friction: wear loose, comfortable cotton clothing, reduce local friction, regular exfoliation, can be localized hot compresses, soften the skin tissue, can effectively alleviate the symptoms of thick knee cuticle. 2. Skin dehydration: you should drink water and eat vitamin-rich foods to replenish the body’s need for water, but also the local use of compound lactic acid cream, vitamin E cream, compound salicylic acid cream and other drugs for treatment. 3. Melanin precipitation: daily life can eat more food containing vitamin C and vitamin E, effectively inhibit the production of melanin in the skin, reduce the local sun exposure. You can use topical vitamin E ointment, urea ointment and other drugs for treatment. In the use of medication, the need to standardize the use of professional physicians under the guidance of unauthorized use, so as not to aggravate the skin lesions.