Seizure initiation and seizure course usually receive more attention than seizure termination and post-seizure status. However, it is of great value to study the corresponding functional changes in seizure termination and postictal state. The reasons are: 1. Most seizures are self-limiting and seizure termination may be due to activation of endogenous antiepileptic seizure initiation mechanisms, and clarification of such mechanisms can help develop more effective drugs for seizure control. 2. Excitability decreases within 24 hours after a seizure, and studying this mechanism can help investigate new treatment strategies to stop seizure initiation or cure epilepsy. 3. The post-seizure state also has a greater impact on patient health and life than the seizure event itself. For example, many patients experience blurred consciousness and memory deficits, generalized weakness, dizziness and headache after a seizure, which can last for several days in severe cases, which is more troublesome for patients. 4. The added value of exploring factors related to seizure termination or post-seizure status lies in the ability to discover mechanisms that influence seizure initiation and thus prevent epilepsy or its critical processes. Currently we are not at the point of stopping seizure initiation and have to discover new targets for the action of antiepileptic drugs. Electrical stimulation of the cerebral cortex triggers post-discharge phenomena that can be eliminated by repeated brief stimulation of the same region, and these brief stimuli can transiently cause an increase in the threshold for seizure induction. Of course the eventual translation of the findings from these trials of direct brain stimulation for epilepsy into clinical application requires further research. Although the seizure termination mechanism is more complex than the seizure initiation mechanism, it must be valuable for the development of a novel drug for seizure control, and future novel drugs are likely to have an antiepileptic effect by affecting seizure termination and post-seizure refractoriness. Therefore, it is important for patients to describe in detail their post-seizure physical status at the time of consultation, which is important in determining seizure severity.