The tPSA total prostate-specific antigen is a general term for prostate-specific antigen. The combination of the two is the total prostate-specific antigen, which can be used clinically as a diagnostic indicator for prostate cancer. When the specific antigen is abnormally high, it often indicates the possibility of prostate cancer. If the total prostate specific antigen is greater than 10ng/ml, it is usually necessary to have a prostate puncture biopsy to confirm the diagnosis. If the prostate-specific antigen is between the normal high value, i.e. 4-10ng/ml, a review is needed to determine if a prostate puncture biopsy is necessary.