Female physiological abnormalities of ovarian development abnormalities

  Abnormal ovarian development accounts for a certain percentage of gynecological outpatient visits. This disease can affect the reproductive function of women, because normal ovulation is the material basis of human reproduction, and abnormal ovarian development can lead to ovulation disorders, thus causing about 30% of female infertility. Therefore, it is important to be alert to the symptoms of abnormal ovarian development so that they can be detected and treated as early as possible.  The causes and symptoms of congenital ovarian anomalies, also known as congenital gonadal dysplasia or Turner syndrome, are due to the lack of an X chromosome in females, which prevents the migration of germ cells or the formation of gonads. The symptoms of this condition are not obvious and do not become apparent until after puberty. Common symptoms include primary amenorrhea, an underdeveloped or hypoplastic uterus, underdeveloped mammary glands, and sparse pubic and axillary hair. Patients are usually short in stature and rarely exceed 150 cm in height in adulthood. Patients often have symptoms of deformities such as shield-shaped chest, low posterior hairline, elbow valgus, and nipples located outside the midclavicular line. More than half of the patients have flaccid skin in the neck.  There are many types of ovarian developmental anomalies, mainly manifested as the following: bilateral or unilateral ovarian hypoplasia Bilateral or unilateral ovarian hypoplasia, more common bilaterally, mostly occurs with sex chromosome aberrations. The disease is often associated with other congenital malformations, such as unilateral ovarian hypoplasia often accompanied by ipsilateral tubal hypoplasia or even absence of the kidney, and may also present with a unicornuate uterus in the affected area.  Ectopic ovaries Ectopic ovaries are formed because the ovaries remain in their embryonic position after formation and do not reach the pelvis. Ectopic ovaries are usually located above the normal ovarian site, such as near the lower part of the kidney, or within the retroperitoneal tissue space, and are often associated with ovarian dysplasia. If the ovary descends excessively, it may be located within the inguinal hernia sac. All ectopic ovaries have a tendency to develop into tumors and should therefore be promptly removed.  Excess ovaries Excess ovaries are ovaries that are in addition to normal ovaries and are usually located away from the ovarian site. They have no clinical symptoms when the ovaries are functioning normally and are only detected during surgery.  Treatment of abnormal ovarian development For the treatment of abnormal ovarian development, time is critical. The earlier the treatment, the better the postoperative recovery.  In adolescent female patients, estrogen treatment can promote breast development, cause slight growth of pubic and axillary hair, and stimulate endometrial hyperplasia.  For adult female patients, estrogen and progestin treatment is currently advocated. Cycle treatment by estrogen and progestin can induce periodic uterine bleeding, resembling menstruation. Also, endometrial cancer can be prevented due to regular exfoliation of the endometrium. For married people, treatment with estrogen and progestin also facilitates sexual life and has a good soothing effect on the patient. In addition, methods such as artificial cycle replacement therapy or Chinese herbal medicine can also be tried.  If a patient with striated ovaries has a karyotype of XY, the ovaries have a high rate of malignancy and should be operated as early as possible.  In order to achieve the best treatment effect, patients with ovarian developmental abnormalities should cooperate with their diet. In general, foods rich in phytoestrogens such as soybeans, lentils, cereals, wheat, black rice, sunflower seeds and onions should be consumed. This is a very safe way to supplement phytoestrogens. Due to low ovarian function, patients are prone to osteoporosis. They should pay attention to calcium supplementation, strengthen physical exercise and reduce the intake of salt, alcohol and coffee to reduce the possibility of osteoporosis.  In order to enhance ovarian function, patients should also pay attention to vitamin E. Vitamin E not only has the effect of enhancing ovarian function, but also has the utility of anti-cellular oxidation and anti-cellular lipid peroxidation, which is useful for female patients to restore ovarian function and slow down aging.