The pain in the middle of the upper abdomen in the middle of the night may be caused by duodenal ulcer, chronic gastritis, acute cholecystitis, pancreatitis and so on. 1. duodenal ulcer: refers to the peptic ulcer that occurs in the duodenum, its main manifestation is regular epigastric pain or discomfort, obvious at night or when hungry, relieved after eating, but also accompanied by abdominal distension, nausea, vomiting and other symptoms, which causes epigastric distension in the middle of the middle of the middle of the night and pain in the hand. 2. Chronic gastritis: refers to a variety of etiological causes of chronic inflammatory lesions of the gastric mucosa, the main manifestations of the upper and middle abdominal discomfort, a feeling of fullness, dull pain, burning pain, can also be accompanied by a loss of appetite, acid reflux, belching (hiccups), nausea, vomiting, and other symptoms, but also can be manifested in the middle of the epigastrium in the middle of the middle of the middle of the middle of the middle of the middle of the night distension pain in the middle of the middle of the middle of the middle of the middle of the middle of the abdomen. 3. Acute cholecystitis: If you eat too much or eat greasy food in the middle of the night, cholecystitis can be triggered, which can also cause distension in the middle of the epigastrium in the middle of the middle of the night and hand pressure pain, the pain is persistent, paroxysmal aggravation, which can be radiated to the right shoulder and back, and it can be accompanied by fever, nausea, vomiting and other symptoms. 4. Pancreatitis: it can also cause epigastric distension in the middle of the middle of the night hand pressure pain, mainly manifested as a sudden onset of severe abdominal pain, to the back of the waist and back dispersion, bending over the knees can be relieved, often accompanied by fever, nausea, vomiting, fever and abdominal distension and other symptoms. There are many other causes of epigastric distension in the middle of the middle of the night and hand pressure pain, should be taken seriously, timely consultation, identify the cause of the disease, and follow the doctor’s instructions for further treatment or treatment.