Both mRNA vaccines and inactivated vaccines are autoimmune preparations for disease prevention made from pathogenic microorganisms such as bacteria and viruses and their metabolites by special preparation methods, which have certain differences in preparation process and principle of action: 1. Preparation process: mRNA vaccines are made by transcribing the DNA of pathogenic microorganisms such as bacteria and viruses and their metabolites into mRNA by transgenic way. Inactivated vaccine is a vaccine made by inactivating pathogenic microorganisms by artificial chemical or physical methods, also known as dead vaccine. 2. The pathogenic microorganisms in inactivated vaccines lose the ability to reproduce in the organism and do not cause disease, but can stimulate the organism to produce specific antibodies or sensitized T lymphocytes, thus generating immunity; 3. Effectiveness evaluation: mRNA vaccines are unstable under physiological conditions, easily degraded, and the preparation process is more complicated, with relatively high efficiency, and the new crown mRNA vaccine has now been authorized under WHO It has been approved for use under WHO authorization. Inactivated vaccines are safe, easy to preserve, and have fewer side effects, and can be made into a combination vaccine, such as a triple vaccine mixed with typhoid and paratyphoid A and B.