The severity of atypical hyperplasia of the gastric sinus mucosa cannot be generalized. Atypical hyperplasia is categorized as mild or moderately severe hyperplasia and needs to be combined with specific endoscopic symptoms in order to determine the severity of the disease. Mild atypical hyperplasia is usually associated with Helicobacter pylori (HP) infection and can be treated with quadruple therapy such as omeprazole, bismuth potassium citrate, clarithromycin, and metronidazole. With systemic treatment, mild atypical hyperplasia of the gastric sinus mucosa can be cured if it is not very severe. If the lesion has progressed to moderate or severe atypical hyperplasia, it may be accompanied by ulcerated erosions or elevated lesions, which should be immediately treated with relevant surgery, endoscopic treatment such as EMR and ESD can be considered, and regular review is needed after the surgery. If the mucosa of gastric sinus is mild atypical hyperplasia, one should be alert to the progression of the disease to moderate or severe atypical hyperplasia or carcinoma. You should go to the hospital for gastroscopy and other related examinations regularly to observe the development of the disease and prevent it from worsening.