Often feel the tongue large tongue root hardness, need to go to the hospital to check whether the development of tongue disease, according to the description may be tongue amyloidosis or burning mouth syndrome. 1. Tongue amyloidosis. The tongue is hard, may be protein metabolism disorders caused by the tongue amyloid lesions, clinical manifestations of the tongue gradually enlarged, with the development of lesions, the tongue will be amyloid deposition aggravated and hard, clinical treatment taking melphalan and prednisone, or the use of immunosuppressants, colchicine. 2. Burning mouth syndrome. Scorch mouth syndrome will appear tongue sensory abnormalities, self-consciousness, numbness, dull pain, tongue hardness, treatment generally remove external stimuli, correct bad oral habits, mental symptoms can be taken glutamine, alprazolam. If necessary, supplemented with psychotherapy. The tongue is large and hard, but also need to be alert to whether the tongue tumor, specific measures need to go to the hospital to identify the cause of the targeted treatment.