The summary report of the International Conference on Biological and Immunological Oncology held in the United States in 2000 pointed out that “biological therapy is the only treatment known to the medical community that is expected to completely destroy cancer cells, and the 21st century is the century of biological oncology therapy”. Biological tumor therapy is a kind of treatment that can achieve anti-tumor effect by mobilizing the host’s natural defense mechanism or giving certain substances to the body. Commonly speaking, it is to enhance the patient’s resistance by using some biological response modifiers such as cytokines, tumor vaccines, plant polysaccharides, etc., so as to achieve the purpose of killing and inhibiting tumors. The main functions of tumor biological therapy are: 1. directly regulating the growth and differentiation of tumor cells, inhibiting tumor growth and shrinking tumor; 2. promoting the development of tumor cells from low differentiation to high differentiation, increasing the sensitivity of tumor cells to human anti-tumor immune response, which is beneficial to kill cancer cells; 3. specifically acting on tumor neovascularization, affecting the nutrient supply of tumor, leading to necrosis of tumor cells, while normal cells are not affected; 4. stimulating the patient’s immune system, which can be used for the treatment of tumor. 4.Stimulate the immune response in the patient’s body, so that more anti-cancer cells can be produced in the body and enhance the anti-cancer ability; 5.Stimulate the hematopoietic function, promote the recovery of bone marrow suppression, so that the patient can tolerate the large dose of radiotherapy or chemotherapy for the whole body, reduce the damage when the patient receives anti-cancer treatment, increase the tolerance of anti-cancer treatment and improve the effect of radiotherapy and chemotherapy. Features of tumor biotherapy: 1. tumor specificity (highly selective); 2. mechanism of action and toxic side effects are different from conventional treatment; 3. not easy to produce drug resistance; 4. less toxic side effects. It is suitable for the treatment of various tumors at different stages of disease (except T-cell lymphoma/tumor): 1. respiratory system: lung cancer (small cell lung cancer, squamous cancer, adenocarcinoma), etc.; 2. digestive system: liver cancer, stomach cancer, intestinal cancer, esophageal cancer, pancreatic cancer, etc.; 3. urinary system: kidney cancer, adrenal cancer, bladder cancer, prostate cancer and its metastatic cancer, etc.; 4. hematological system: acute and chronic leukemia, lymphoma (except T-cell lymphoma). lymphoma). 5.Other tumors: malignant melanoma, nasopharyngeal cancer, breast cancer, tongue cancer, etc. Significant effect of thoracoabdominal perfusion treatment for pleural fluid and ascites. Recommended combined CIK/DC treatment plan Post-operative + CIK/DC: Rapid recovery of immune damage caused by surgery, specific removal of tiny residual tumor lesions after surgery, prevention of metastasis and recurrence. Radiotherapy + CIK/DC: enhance the sensitivity of radiotherapy, reduce the toxic side effects of radiotherapy; promote the body’s immune reconstruction. Chemotherapy + CIK/DC: enhance sensitivity to chemotherapy drugs; resist immunosuppressive effect of chemotherapy drugs; support immune reconstruction after bone marrow failure. Conventional treatment is ineffective CIK/DC alone: directly kill tumor cells; produce a large number of inflammatory cells to inhibit tumor and kill tumor after activation; induce apoptosis of tumor cells; promote proliferation and activation of T cells; improve the immunity of the body.