Low total serum protein may be associated with malnutrition, liver disease, chronic wasting disease, burns, etc. Total serum protein is divided into two categories: albumin and globulin, which have important physiological functions in the organism, maintaining normal colloid osmotic pressure and pH value of the blood, transporting a variety of metabolites and many other functions. 1. Malnutrition: long-term partiality, picky eating, unhealthy diet, etc., resulting in insufficient intake of protein in food, the total serum protein is reduced. 2. Liver diseases: such as cirrhosis, etc., the liver’s synthetic ability decreases, the synthesis of protein decreases, resulting in a decrease in total protein. 3. Chronic consumptive diseases: such as tuberculosis, malignant tumors, etc., long-term consumption of protein in the body, manifested as a decrease in total protein. 4. Burns: severe large-area burns, excessive loss of protein stored in the body, can also lead to a decrease in total protein. There are other causes of low serum total protein, and it is recommended that patients seek medical treatment in time to avoid delaying their condition.