The pain of drinking water in patients with bile duct stones may be caused by bile duct obstruction due to stones and acute cholangitis induced by bacterial infection. Acute cholangitis is an infectious disease of the bile duct caused by secondary infection after partial or complete obstruction of the bile duct, mostly due to intrahepatic and extrahepatic bile duct stones, benign bile duct stenosis, and malignant diseases, and is typically characterized by Charcot’s triad (fever, jaundice and abdominal pain). For relief of pain symptoms, relief of biliary obstruction is the most important. For low-level obstruction such as stones in the lower part of the common bile duct, placement of a nasobiliary tube or removal of stones under ERCP (endoscopic retrograde cholangiopancreatography) can be considered; for high-level obstruction above the confluence of the right and left hepatic ducts, drainage of bile under PTCD (percutaneous hepatic perforation with choledocholithiasis) can be considered. It is recommended that patients with bile duct stones go to regular hospitals in time to avoid delay in diagnosis and treatment.