The main symptoms of nephrotic syndrome are “three highs and one low”, i.e. massive proteinuria, edema, hyperlipidemia, hypoproteinemia, accompanied by hypertension, hematuria, loss of appetite and other symptoms. 1. Massive proteinuria: Massive proteinuria refers to the loss of up to 3.0-3.5g of protein from urine per day, and 50mg/kg in children; Massive proteinuria occurs due to the abnormal permeability of glomerular filtration membrane, i.e., mechanical barrier and charge barrier damage. Increased foam in urine can be seen. 2. Edema: due to the loss of large amount of protein, it can lead to the occurrence of edema; nephrogenic edema mostly starts with the face and is more obvious in the morning. 3. Hyperlipidemia: mainly manifested as hypercholesterolemia and/or hypertriglyceridemia, which may be accompanied by the elevation of LDL, VLDL and lipoproteins, while HDL is normal or reduced. 4. Hypoalbuminemia: Hypoalbuminemia occurs when the increase in hepatic albumin synthesis is insufficient to overcome the loss and catabolism. Prolonged loss of protein can lead to malnutrition and growth retardation. 5. Other symptoms: such as hypertension, hematuria and so on are one of the common accompanying symptoms of nephrotic syndrome, in addition, patients may also suffer from loss of appetite. It is recommended that patients with nephrotic syndrome should consult a doctor in time and follow the doctor’s instructions.