Bone pain in the front of the calf when walking is particularly common in daily life and is mainly due to the following reasons. In the first case, running, jumping, or walking long distances or doing high-intensity physical exercise can lead to local injury or strain, which can induce the appearance of pain. In the second case, the pain may be due to fatigue periostitis of the tibiofibula. In the third case, the pain may be triggered by tibial tubercle and epiphysitis. In the case of pain in the front bone when walking, it is recommended that the patient apply local heat, massage, or apply blood circulation, anti-inflammatory and analgesic drugs to assist in the treatment.