The consequences of long-term use of tenofovir include lowering the chance of liver cancer, causing kidney damage and hypophosphatemia. 1. Reduce the chance of liver cancer: Hepatitis B virus is easy to induce cirrhosis and even liver cancer if it is not effectively controlled, taking Tenofovir can help to control the replication of hepatitis B virus and effectively reduce the chance of liver cancer. 2. Causing liver damage: Tenofovir is a nucleoside antiviral drug, when taken for a long time, because the drug needs to be metabolized by the kidney, so it may cause the risk of kidney damage, it is generally recommended that patients need to undergo regular liver function tests, and once liver function abnormalities occur, it is necessary to consider changing the drug. 3. cause hypophosphatemia: nucleoside analogues need to be metabolized by the kidneys, filtered through the glomerulus, and then secreted by the renal tubules to become urine excreted, the drug metabolism is relatively slow, easy to cause the renal proximal tubular accumulation, resulting in the renal tubules by toxicity of the infringement of the renal tubules, resulting in renal tubules can not reabsorption of phosphorus, calcium, and potassium and other substances, resulting in a decrease in blood phosphorus, prone to cause osteoporosis. Adverse effects of Tenofovir include nausea, dizziness, headache, diarrhea, and insomnia, etc. It is contraindicated for those who are allergic to Tenofovir. In addition, the above drugs have certain risks, patients need to get the guidance of a specialist, do not be negligent, so as not to delay the condition.